Celiac and Collagenous Sprue

Celiac disease is also known as non-tropical sprue or celiac sprue. It is a hereditary auto-immune disease.

(Tropical sprue is a disease with basically the same symptoms as Celiac disease but the cause is unknown)

Collagenous  sprue has been defined as a (small) intestinal mucosal disorder that causes multiple nutrient deficiancies, weight loss, chronic diarrhea and severe malabsorption.  It is believed that Collagenous sprue is the result non-responsive Celiac disease.

 In other words, if a Celiac on a gluten free diet does not have improvement in the condition of the villi in the small intestine, they can develop collagenous sprue.

Collagenous sprue is rare.

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